Re-sequencing of a virulent strain of Campylobacter jejuni NCTC11168 reveals potential virulence factors

Kerry K. Cooper, Margarethe A. Cooper, Andrea Zuccolo, Lynn A. Joens

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In vitro passage of Campylobacter jejuni strains results in phenotypic changes and a general loss of virulence, as is the case with the genome-sequenced strain C. jejuni NCTC11168. Re-sequencing of a virulent strain of NCTC11168 identified 41 SNPs or indels involving 20 genes, four intergenic regions and three pseudogenes. The genes include six motility genes, two chemotaxis genes, three hypothetical genes and a capsule biosynthesis gene, which might have a critical role in C. jejuni virulence. Additionally, we found an insertion in both Cj0676 and Cj1470c, pseudogenes in avirulent NCTC11168, but functional proteins in virulent NCTC11168.

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalResearch in Microbiology
Volume164
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Campylobacter jejuni
  • Genome sequencing
  • NCTC11168
  • SNPs
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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