Rare monosomy 7 and deletion 7p at diagnosis of chronic myeloid leukemia in accelerated phase

Abdullah Alswied, Aseeb Rehman, Li Wen Lai, Juanita Duran, Muhammad Sardar, Maria A. Proytcheva

Research output: Contribution to journalArticlepeer-review

Abstract

Clonal cytogenic evolution with the development of additional chromosomal abnormalities (ACAs) in chronic myelogenous leukemia (CML) is a marker for disease progression and is known to impact therapy and survival. The presence of ACAs has been shown to affect the responses to tyrosine kinase inhibitors (TKI) in patients with newly diagnosed CML in accelerated phase (CML-AP). We report a rare case of a CML patient who presented in CML-AP and was found to have multiple ACAs including monosomy 7, deletion 7p, trisomy 8, and an extra Philadelphia chromosome (Ph) in separate Ph-positive cell line, respectively. Six months after combined chemotherapy with TKI, the patient achieved a major cytogenetic response with disappearance of monosomy 7/deletion 7p with no major molecular response.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalCancer Genetics
Volume252-253
DOIs
StatePublished - Apr 2021

Keywords

  • Additional chromosomal abnormalities
  • Chronic myelogenous leukemia
  • Clonal cytogenic evolution
  • Deletion 7p
  • Monosomy 7
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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