TY - JOUR
T1 - Rapid elevation of rat serum prolactin concentration by cyclosporine, a novel immunosuppressive drug
AU - Cardon, Stephan B.
AU - Larson, Douglas F.
AU - Russell, Diane Haddock
PY - 1984/4/30
Y1 - 1984/4/30
N2 - Within one hr of the administration of cyclosporine to rats, there was a 4-fold elevation in the serum prolactin concentration. Doses of 0.12, 1.2, and 12 μg/100 g body weight cyclosporine significantly elevated the serum prolactin level. Higher doses, 120 or 1200 μg/100 g body weight cyclosporine resulted in small but insignificant elevations of the serum prolactin concentration. Bromocriptine, a dopamine agonist which inhibits prolactin release from the anterior pituitary, completely blocked the elevation in serum prolactin in response to cyclosporine alone. These data suggest that the ability of cyclosporine to suppress immune function may involve its ability to rapidly produce hyperprolactinemia.
AB - Within one hr of the administration of cyclosporine to rats, there was a 4-fold elevation in the serum prolactin concentration. Doses of 0.12, 1.2, and 12 μg/100 g body weight cyclosporine significantly elevated the serum prolactin level. Higher doses, 120 or 1200 μg/100 g body weight cyclosporine resulted in small but insignificant elevations of the serum prolactin concentration. Bromocriptine, a dopamine agonist which inhibits prolactin release from the anterior pituitary, completely blocked the elevation in serum prolactin in response to cyclosporine alone. These data suggest that the ability of cyclosporine to suppress immune function may involve its ability to rapidly produce hyperprolactinemia.
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U2 - 10.1016/0006-291X(84)91299-3
DO - 10.1016/0006-291X(84)91299-3
M3 - Article
C2 - 6732774
AN - SCOPUS:0021270495
SN - 0006-291X
VL - 120
SP - 614
EP - 618
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -