Rapid Diagnosis of Pulmonary Coccidioidomycosis: Cytologic v Potassium Hydroxide Preparations

Michael A. Warlick, Stuart F. Quan, Richard E. Sobonya

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


In 26 patients with culture-proved pulmonary coccidioidomycosis, cytologic preparations of respiratory secretions were significantly more sensitive (38.5%) than potassium hydroxide (KOH) preparations (15.4%) in identifying spherules of Coccidioides immitis. Those patients able to produce sputum or having multiple-lobe pneumonitis on chest roentgenogram appeared to be more likely to have spherules identified in the sputum by either technique. In the absence of sputum production or multiple-lobe pneumonitis, neither cytologic nor KOH preparations were likely to disclose spherules. Because of its greater sensitivity, a cytologic preparation should be examined in addition to a KOH preparation when pulmonary coccidioidomycosis is a clinical consideration.

Original languageEnglish (US)
Pages (from-to)723-725
Number of pages3
JournalArchives of internal medicine
Issue number4
StatePublished - Apr 1983
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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