Randomized Pilot Trial on Optimal Treatment Strategy, Myocardial Changes, and Prognosis of Patients with Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA)

Rokas Serpytis, Egle Majauskiene, Petras Navickas, Mindaugas Lizaitis, Sigita Glaveckaite, Kestutis Rucinskas, Zaneta Petrulioniene, Nomeda Valeviciene, Robertas Stasys Samalavicius, Andrius Berukstis, Arvydas Baranauskas, Urte Gargalskaite, Aleksandras Laucevicius, Qin M. Chen, Joseph S. Alpert, Pranas Serpytis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Myocardial infarction with nonobstructive coronary arteries (MINOCA) remains an unresolved challenge. Many different diagnostic approaches are often required to diagnose, confirm, and evaluate MINOCA. The prevalence can be as high as 13% of all acute myocardial infarction patients, indicating that this condition is not rare. At this time, there have been no completed randomized clinical trials involving MINOCA patients, and a better understanding of the mechanisms and management of these patients is important. This exploratory analysis seeks to find possible etiologic factors, the value of novel biomarkers, and the effect of different treatment strategies in patients with MINOCA. Methods: This prospective randomized pilot trial will include 150 patients with MINOCA. A thorough clinical, laboratory, and imaging evaluation will be performed, including novel biomarkers and modern imaging techniques (heart magnetic resonance imaging and noninvasive testing). The duration of the enrollment is 18 months, and duration of the follow-up is 12 months from the enrollment of the first patient. Results: The trial is registered under www.clinicaltrials.gov: NCT04538924. The study is currently recruiting participants. Conclusions: Because MINOCA is not a benign disease, the results of the current investigation could inform future diagnostic and therapeutic strategies and enhance the understanding of MINOCA patients.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalAmerican Journal of Medicine
Volume135
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • MINOCA
  • Myocardial infarction
  • Myocardial infarction with nonobstructive coronary arteries

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Randomized Pilot Trial on Optimal Treatment Strategy, Myocardial Changes, and Prognosis of Patients with Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA)'. Together they form a unique fingerprint.

Cite this