TY - JOUR
T1 - Randomized crossover comparison of high-dose intravenous metoclopramide versus a five-drug antiemetic regimen
AU - Plezia, Patricia M.
AU - Alberts, David S.
AU - Kessler, John F.
AU - Berens, Patricia L.
AU - Chase, Judy L.
AU - Roe, Denise J.
N1 - Funding Information:
We would like to thank Vickie Wihon and the nursing staff of the Arizona Cancer Center for their clinical assistance. This work was supported by Grants CA 17094 and CA 25024 Cancer Center Core from the National Institutes of Health, Betheeda, Maryland, and a donation from the Phi Beta Psi National Sorority.
PY - 1990
Y1 - 1990
N2 - In a randomized open crossover study, the antiemetic efficacy of a five-drug antiemetic regimen consisting of metoclopramide, dexamethasone, diazepam, diphenhydramine, and hylperazine was compared to that of high-dose metoclopramide. Thirteen patients treated with cisplatin combination chemotherapy regimens were evaluated. The study was terminated prior to accrual of the planned number of patients because of the statistically significant difference in efficacy between treatments found at interim analysis. The Suration of nausea and number of vomiting episodes on the day of chemotherapy were significantly less (p < 0.01) after receiving the five-drug combination. After receiving the five-drug regimen, 77% of the patients did not experience any episodes of vomiting on day 1, and 8% of patients had only one episode. In contrast, only 31% of patients treated with high-dose metoclopramide did not have any episodes of vomiting on day 1, and 61% of the patients had five or more episodes. None of the patients treated with the five-drug regimen required additional antiemetic administration. Although both regimens were, in general, well tolerated, when given the choice of continuing antiemetic therapies, 92% of the patients preferred the five-drug antiemetic combination.
AB - In a randomized open crossover study, the antiemetic efficacy of a five-drug antiemetic regimen consisting of metoclopramide, dexamethasone, diazepam, diphenhydramine, and hylperazine was compared to that of high-dose metoclopramide. Thirteen patients treated with cisplatin combination chemotherapy regimens were evaluated. The study was terminated prior to accrual of the planned number of patients because of the statistically significant difference in efficacy between treatments found at interim analysis. The Suration of nausea and number of vomiting episodes on the day of chemotherapy were significantly less (p < 0.01) after receiving the five-drug combination. After receiving the five-drug regimen, 77% of the patients did not experience any episodes of vomiting on day 1, and 8% of patients had only one episode. In contrast, only 31% of patients treated with high-dose metoclopramide did not have any episodes of vomiting on day 1, and 61% of the patients had five or more episodes. None of the patients treated with the five-drug regimen required additional antiemetic administration. Although both regimens were, in general, well tolerated, when given the choice of continuing antiemetic therapies, 92% of the patients preferred the five-drug antiemetic combination.
KW - Antiemetic combinations
KW - cisplatin
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U2 - 10.1016/S0885-3924(05)80023-5
DO - 10.1016/S0885-3924(05)80023-5
M3 - Article
C2 - 2189929
AN - SCOPUS:85049057184
SN - 0885-3924
VL - 5
SP - 101
EP - 108
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
IS - 2
ER -