Radiosensibilité individuelle: Les tests vont changer nos pratiques

Translated title of the contribution: Intrinsic radiosensitivity: Predictive assays that will change the daily practice

J. Lacombe, O. Riou, J. Solassol, A. Mangé, C. Bourgier, P. Fenoglietto, A. Pèlegrin, M. Ozsahin, D. Azria

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in principle non-reversible. This review details the different radiobiological approaches that have been developed to better understand the mechanisms of radiation-induced late effects. We also present the possibilities of clinical use of predictive assays in the close future.

Translated title of the contributionIntrinsic radiosensitivity: Predictive assays that will change the daily practice
Original languageFrench
Pages (from-to)337-343
Number of pages7
JournalCancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Volume17
Issue number5-6
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Late effects
  • Predictive assays
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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