Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Anthony P. Young; Vahe Bandarian

doi:10.1016/j.cbpa.2013.05.035

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Anthony P. Young
, Vahe Bandarian

Chemistry and Biochemistry

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNA^Phe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.

Original language	English (US)
Pages (from-to)	613-618
Number of pages	6
Journal	Current Opinion in Chemical Biology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.cbpa.2013.05.035
State	Published - Aug 2013

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/j.cbpa.2013.05.035

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title = "Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine",

abstract = "Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNAPhe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.",

author = "Young, \{Anthony P.\} and Vahe Bandarian",

note = "Funding Information: Research reported in this publication was supported by the National Institute of General Medical Science of the National Institutes of Health under award number R01 GM72623. Additional support from a Career Award in Biomedical Sciences from the Burroughs Wellcome Fund (to V.B.) is also acknowledged.",

year = "2013",

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doi = "10.1016/j.cbpa.2013.05.035",

language = "English (US)",

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pages = "613--618",

journal = "Current Opinion in Chemical Biology",

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T1 - Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

AU - Young, Anthony P.

AU - Bandarian, Vahe

N1 - Funding Information: Research reported in this publication was supported by the National Institute of General Medical Science of the National Institutes of Health under award number R01 GM72623. Additional support from a Career Award in Biomedical Sciences from the Burroughs Wellcome Fund (to V.B.) is also acknowledged.

PY - 2013/8

Y1 - 2013/8

N2 - Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNAPhe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.

AB - Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNAPhe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.

UR - https://www.scopus.com/pages/publications/84881262345

UR - https://www.scopus.com/pages/publications/84881262345#tab=citedBy

U2 - 10.1016/j.cbpa.2013.05.035

DO - 10.1016/j.cbpa.2013.05.035

M3 - Review article

C2 - 23856057

AN - SCOPUS:84881262345

SN - 1367-5931

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SP - 613

EP - 618

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

IS - 4

ER -

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

Abstract

ASJC Scopus subject areas

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