TY - JOUR
T1 - Radical-mediated ring contraction in the biosynthesis of 7-deazapurines
AU - Bandarian, Vahe
AU - Drennan, Catherine L.
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of General Medical Science of the National Institutes of Health under award number R01 GM72623 . Additional support from a Career Award in Biomedical Sciences from the Burroughs Wellcome Fund (to V.B.) is also acknowledged. C.L.D. is a Howard Hughes Medical Investigator.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
AB - Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
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U2 - 10.1016/j.sbi.2015.11.005
DO - 10.1016/j.sbi.2015.11.005
M3 - Review article
C2 - 26643180
AN - SCOPUS:84948775336
SN - 0959-440X
VL - 35
SP - 116
EP - 124
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -