Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

Hexin Xie, Aiguo Song, Xinshuai Zhang, Xiaobei Chen, Hao Li, Chunquan Sheng, Wei Wang

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalChemical Communications
Issue number9
StatePublished - Jan 2 2013
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • General Chemistry
  • Catalysis


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