Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

Hexin Xie; Aiguo Song; Xinshuai Zhang; Xiaobei Chen; Hao Li; Chunquan Sheng; Wei Wang

doi:10.1039/c2cc38097h

Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

Hexin Xie, Aiguo Song, Xinshuai Zhang, Xiaobei Chen, Hao Li, Chunquan Sheng, Wei Wang

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.

Original language	English (US)
Pages (from-to)	928-930
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	9
DOIs	https://doi.org/10.1039/c2cc38097h
State	Published - Jan 2 2013
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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AU - Xie, Hexin

AU - Song, Aiguo

AU - Zhang, Xinshuai

AU - Chen, Xiaobei

AU - Li, Hao

AU - Sheng, Chunquan

AU - Wang, Wei

PY - 2013/1/2

Y1 - 2013/1/2

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AB - An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.

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Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones

Abstract

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