Quinine-catalyzed enantioselective michael addition of diphenyl phosphite to nitroolefins: Synthesis of chiral precursors of α-substituted β-aminophosphonates

Jian Wang, Lora D. Heikkinen, Hao Li, Liansuo Zu, Wei Jiang, Hexin Xie, Wei Wang

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

A quinine-promoted, enantioselective Michael addition reaction of diphenyl phosphite with nitroalkenes has been developed. This methodology affords a facile access to enantiomerically enriched β-nitrophosphates, precursors for the preparation of synthetically and biologically useful β-aminophosphonates.

Original languageEnglish (US)
Pages (from-to)1052-1056
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume349
Issue number7
DOIs
StatePublished - May 2007
Externally publishedYes

Keywords

  • Amino acids
  • Asymmetric catalysis
  • Michael addition
  • Organic catalysis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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