Quinidine-Digoxin Interaction

Teut Risler; Uwe Peters; Bernd Grabensee; Ludger Seipel; St George T. Lee; Karl David Straub; Knud E. Pedersen; Steffen Hvidt; J. Robert Powell; Paul E. Fenster; W. David Hager; Penelope Graves; Michael Wandell; Kenneth Conrad; W. Doering

doi:10.1056/NEJM198001173020314

Quinidine-Digoxin Interaction

Teut Risler, Uwe Peters, Bernd Grabensee, Ludger Seipel, St George T. Lee, Karl David Straub, Knud E. Pedersen, Steffen Hvidt, J. Robert Powell, Paul E. Fenster, W. David Hager, Penelope Graves, Michael Wandell, Kenneth Conrad, W. Doering

Research output: Contribution to journal › Letter › peer-review

7 Scopus citations

Abstract

To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study¹ that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.

Original language	English (US)
Pages (from-to)	175-177
Number of pages	3
Journal	New England Journal of Medicine
Volume	302
Issue number	3
DOIs	https://doi.org/10.1056/NEJM198001173020314
State	Published - Jan 17 1980
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1056/NEJM198001173020314

Cite this

@article{e993c4afea974d34905dcfe4639e9b9a,

title = "Quinidine-Digoxin Interaction",

abstract = "To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study1 that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.",

author = "Teut Risler and Uwe Peters and Bernd Grabensee and Ludger Seipel and Lee, \{St George T.\} and Straub, \{Karl David\} and Pedersen, \{Knud E.\} and Steffen Hvidt and Powell, \{J. Robert\} and Fenster, \{Paul E.\} and Hager, \{W. David\} and Penelope Graves and Michael Wandell and Kenneth Conrad and W. Doering",

year = "1980",

month = jan,

day = "17",

doi = "10.1056/NEJM198001173020314",

language = "English (US)",

volume = "302",

pages = "175--177",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "3",

}

TY - JOUR

T1 - Quinidine-Digoxin Interaction

AU - Risler, Teut

AU - Peters, Uwe

AU - Grabensee, Bernd

AU - Seipel, Ludger

AU - Lee, St George T.

AU - Straub, Karl David

AU - Pedersen, Knud E.

AU - Hvidt, Steffen

AU - Powell, J. Robert

AU - Fenster, Paul E.

AU - Hager, W. David

AU - Graves, Penelope

AU - Wandell, Michael

AU - Conrad, Kenneth

AU - Doering, W.

PY - 1980/1/17

Y1 - 1980/1/17

N2 - To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study1 that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.

AB - To the Editor: We read with great interest Dr. Doering's article on the digoxin-quinidine interaction in the August 23 issue. Although we agree with most of his findings, we would like to present some additional results from our study1 that suggest a different mechanism of the digoxin-quinidine interaction. In our study serum concentrations of digoxin and quinidine as well as urinary levels of digoxin were measured in 11 volunteers under steady-state conditions (0.375 mg of digoxin per day). The group's mean (±S.D.) serum digoxin concentration was 0.75±0.2 ng per milliliter before and 1.2±0.4 ng per milliliter after (P<0.0001) concomitant administration.

UR - https://www.scopus.com/pages/publications/0018915122

UR - https://www.scopus.com/inward/citedby.url?scp=0018915122&partnerID=8YFLogxK

U2 - 10.1056/NEJM198001173020314

DO - 10.1056/NEJM198001173020314

M3 - Letter

C2 - 7350448

AN - SCOPUS:0018915122

SN - 0028-4793

VL - 302

SP - 175

EP - 177

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 3

ER -

Quinidine-Digoxin Interaction

Abstract

ASJC Scopus subject areas

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