Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

Béatrice Hauss-Wegrzyniak; Jean Philippe Galons; Gary L. Wenk

doi:10.1006/exnr.2000.7469

Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

Béatrice Hauss-Wegrzyniak, Jean Philippe Galons, Gary L. Wenk

Medical Imaging

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	347-354
Number of pages	8
Journal	Experimental Neurology
Volume	165
Issue number	2
DOIs	https://doi.org/10.1006/exnr.2000.7469
State	Published - 2000

Keywords

Alzheimer's disease
Brain inflammation
Hippocampus
Magnetic resonance imaging
Rats

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1006/exnr.2000.7469

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title = "Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation",

abstract = "Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.",

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note = "Funding Information: This work was supported in part by the National Institute of Aging, ROI AG10546; an Alzheimer{\textquoteright}s Association Investigator-Initiated Research Grant, IIRG-95-004; and the Flinn Foundation. We thank Dr. T. Trouard for helpful discussion and expert advice.",

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AU - Hauss-Wegrzyniak, Béatrice

AU - Galons, Jean Philippe

AU - Wenk, Gary L.

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AB - Brain inflammation may have a pathogenic role in many neurodegenerative diseases, including Alzheimer's disease. In the present study, we investigated the effects of chronic neuroinflammation upon anatomical changes in two regions of interest in the temporal lobe using high-resolution magnetic resonance imaging techniques. We show that chronic infusion of lipopolysaccharide into the fourth ventricle for 4 consecutive weeks enlarged the lateral ventricles and significantly decreased the size of the hippocampal formation and the temporal lobe region. These changes are comparable to those observed in humans during the early stages of Alzheimer's disease. (C) 2000 Academic Press.

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KW - Magnetic resonance imaging

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Quantitative volumetric analyses of brain magnetic resonance imaging from rat with chronic neuroinflammation

Abstract

Keywords

ASJC Scopus subject areas

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