Quantitative Studies of Diabetic Foot Ulcer Evolution Under Treatment by Digital Stereotactic Photography

Carlos Alberto Cabal Mirabal, Jorge Berlanga Acosta, José Fernández Montequín, Leonardo Oramas Díaz, Evelio González Dalmau, Luis Herrera Martínez, José Esteban Sauri, Julio Baldomero Hernández, Wiliam Savigne Gutiérrez, Jorge Luis Valdés, Ana Ledia Tabio Reyes, Salome Carmen Pérez Pérez, Calixto Valdés Pérez, Alexandria A. Armstrong, David G. Armstrong

Research output: Contribution to journalArticlepeer-review


Background: Imaging the lower extremity reproducibly and accurately remains an elusive goal. This is particularly true in the high risk diabetic foot, where tissue loss, edema, and color changes are often concomitant. The purpose of this study was to evaluate the reproducibility of a novel and inexpensive stereotaxic frame in assessment of wound healing. Methods: The main idea is to keep constant and reproducible the relative position of extremities related to the sensor used for the examination during a serial studies by stereotaxic digital photographic sequence. Ten healthy volunteers were evaluated at 10 different time moments to estimate the foot position variations in the stereotaxic frame. The evolution of 40 of DFU patients under treatment was evaluated before and during the epidemical grow factor intralesional treatment. Results: The wound closing and granulation speeds, the relative contribution of the contraction and tissue restauration mechanism were evaluated by stereotaxic digital photography. Conclusions: The results of this study suggest that the stereotaxic frame is a robust platform for serial study of the evolution of wound healing which allow to obtain consistent information from a variety of visible and hyperspectral measurement technologies. New stereotaxic digital photography evidences related to the diabetic foot ulcer healing process under treatment has been presented.

Original languageEnglish (US)
Pages (from-to)821-826
Number of pages6
JournalJournal of Diabetes Science and Technology
Issue number5
StatePublished - Sep 1 2019
Externally publishedYes


  • diabetic foot ulcer
  • imaging
  • quantitative evolution
  • serial studies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Bioengineering
  • Biomedical Engineering


Dive into the research topics of 'Quantitative Studies of Diabetic Foot Ulcer Evolution Under Treatment by Digital Stereotactic Photography'. Together they form a unique fingerprint.

Cite this