Quantitative studies of binding between synthetic galactosyl ceramide analogues and HIV-1 gp120 at planar membrane surfaces

Yingmei Gu; Rachel LaBell; David F. O'Brien; S. Scott Saavedra

doi:10.1002/1521-3773(20010618)40:12<2320::AID-ANIE2320>3.0.CO;2-X

Quantitative studies of binding between synthetic galactosyl ceramide analogues and HIV-1 gp120 at planar membrane surfaces

Yingmei Gu, Rachel LaBell, David F. O'Brien, S. Scott Saavedra

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgpl20 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gpl20.

Original language	English (US)
Pages (from-to)	2320-2322
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	12
DOIs	https://doi.org/10.1002/1521-3773(20010618)40:12<2320::AID-ANIE2320>3.0.CO;2-X
State	Published - Jun 18 2001

Keywords

Fluorescence spectroscopy
Glycoproteins
HIV
Sphingolipids
Structure-activity relationships

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/1521-3773(20010618)40:12<2320::AID-ANIE2320>3.0.CO;2-X

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abstract = "A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgpl20 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gpl20.",

keywords = "Fluorescence spectroscopy, Glycoproteins, HIV, Sphingolipids, Structure-activity relationships",

author = "Yingmei Gu and Rachel LaBell and O'Brien, {David F.} and Saavedra, {S. Scott}",

year = "2001",

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T1 - Quantitative studies of binding between synthetic galactosyl ceramide analogues and HIV-1 gp120 at planar membrane surfaces

AU - Gu, Yingmei

AU - LaBell, Rachel

AU - O'Brien, David F.

AU - Saavedra, S. Scott

PY - 2001/6/18

Y1 - 2001/6/18

N2 - A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgpl20 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gpl20.

AB - A critical spacer arm length necessary to promote efficient binding of the HIV-1 surface glycoprotein rgpl20 to several synthetic galactosyl-conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for gpl20.

KW - Fluorescence spectroscopy

KW - Glycoproteins

KW - HIV

KW - Sphingolipids

KW - Structure-activity relationships

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JF - Angewandte Chemie - International Edition

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ER -

Quantitative studies of binding between synthetic galactosyl ceramide analogues and HIV-1 gp120 at planar membrane surfaces

Abstract

Keywords

ASJC Scopus subject areas

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