Quantitative methods for assessing a synergistic or potentiated genotoxic response

Walter W. Piegorsch; Barry H. Margolin

doi:10.1016/0165-1161(89)90017-4

Quantitative methods for assessing a synergistic or potentiated genotoxic response

Walter W. Piegorsch, Barry H. Margolin

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Mutation Research/Environmental Mutagenesis and Related Subjects
Volume	216
Issue number	1
DOIs	https://doi.org/10.1016/0165-1161(89)90017-4
State	Published - Feb 1989
Externally published	Yes

Keywords

Binary data
Chromosome aberrations
Factorial experiments
Fluctuation assay
Interaction
Simple independent action
Simple similar action

ASJC Scopus subject areas

Toxicology
Genetics

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10.1016/0165-1161(89)90017-4

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abstract = "The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.",

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AB - The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.

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KW - Chromosome aberrations

KW - Factorial experiments

KW - Fluctuation assay

KW - Interaction

KW - Simple independent action

KW - Simple similar action

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Quantitative methods for assessing a synergistic or potentiated genotoxic response

Abstract

Keywords

ASJC Scopus subject areas

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