Quantification of toxic response and the development of the median effective dose (ED50)—a historical perspective

Walter W. Piegorsch

doi:10.1177/074823378900500105

Quantification of toxic response and the development of the median effective dose (ED50)—a historical perspective

Walter W. Piegorsch

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The development of the widely-used median effective (or lethal) dose as a summary measure in quantifying toxic response to chemical stimuli is reviewed. Attention is directed at those mathematical properties noted by the originator of the median effective dose, the English physiologist John William Trevan, that make the measure a useful summary statistic for toxicological studies. Consideration is also given to the development of precursor measures to the median effective dose, such as minimal effective dose.

Original language	English (US)
Pages (from-to)	55-62
Number of pages	8
Journal	Toxicology and Industrial Health
Volume	5
Issue number	1
DOIs	https://doi.org/10.1177/074823378900500105
State	Published - Jan 1989
Externally published	Yes

Keywords

history of science
median lethal dose
sigmoid response curve

ASJC Scopus subject areas

Toxicology
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1177/074823378900500105

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Quantification of toxic response and the development of the median effective dose (ED50)—a historical perspective

Abstract

Keywords

ASJC Scopus subject areas

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