QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Frances A. Tylavsky; Timothy Lohman; Barbara A. Blunt; Dale A. Schoeller; Thomas Fuerst; Jane A. Cauley; Michael C. Nevitt; Marjolein Visser; Tamara B. Harris

doi:10.1152/japplphysiol.00732.2002

QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Frances A. Tylavsky, Timothy Lohman, Barbara A. Blunt, Dale A. Schoeller, Thomas Fuerst, Jane A. Cauley, Michael C. Nevitt, Marjolein Visser, Tamara B. Harris

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

Original language	English (US)
Pages (from-to)	959-965
Number of pages	7
Journal	Journal of Applied Physiology
Volume	94
Issue number	3
DOIs	https://doi.org/10.1152/japplphysiol.00732.2002
State	Published - Mar 1 2003
Externally published	Yes

Keywords

Body composition
Dual-energy X-ray absorptiometer
Four-component model of body composition
Hydration of fat-free mass
Total body water

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1152/japplphysiol.00732.2002

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title = "QDR 4500A DXA overestimates fat-free mass compared with criterion methods",

abstract = "This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.",

keywords = "Body composition, Dual-energy X-ray absorptiometer, Four-component model of body composition, Hydration of fat-free mass, Total body water",

author = "Tylavsky, {Frances A.} and Timothy Lohman and Blunt, {Barbara A.} and Schoeller, {Dale A.} and Thomas Fuerst and Cauley, {Jane A.} and Nevitt, {Michael C.} and Marjolein Visser and Harris, {Tamara B.}",

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AU - Tylavsky, Frances A.

AU - Lohman, Timothy

AU - Blunt, Barbara A.

AU - Schoeller, Dale A.

AU - Fuerst, Thomas

AU - Cauley, Jane A.

AU - Nevitt, Michael C.

AU - Visser, Marjolein

AU - Harris, Tamara B.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

AB - This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.

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KW - Dual-energy X-ray absorptiometer

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KW - Hydration of fat-free mass

KW - Total body water

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QDR 4500A DXA overestimates fat-free mass compared with criterion methods

Abstract

Keywords

ASJC Scopus subject areas

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