Abstract
The biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum requires the construction of four units: the amino sugar from glucose; the anthranilate ring from dl-tryptophan probably via kynurenine; the aromatic methyl group from methionine; the propylidene proline from l-tyrosine with the loss of two aromatic carbons and addition of a C-l from methionine. Retention of tritium from dl-[5-3H]tryptophan in sibiromycin suggests an NIH shift during hydroxylation of an intermediate.
Original language | English (US) |
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Pages (from-to) | 4225-4229 |
Number of pages | 5 |
Journal | Biochemistry |
Volume | 18 |
Issue number | 19 |
DOIs | |
State | Published - 1979 |
ASJC Scopus subject areas
- Biochemistry