Abstract
Biosynthetic intermediates between tryptophan and the anthranilate mioeties of tomaymycin and sibiromycin have been suggested, based upon a combination of feeding experiments with either carbon-14-labeled substrates or competition experiments between radiolabeled tryptophan and unlabeled intermediates. In the case of sibiromycin and tomaymycin, substitution of the aromatic ring most likely takes place at the kynurenine stage. Feeding experiments with the antramycin culture were inconclusive, most likely because of the cell impermeability.
Original language | English (US) |
---|---|
Pages (from-to) | 42-45 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases