Putative population of adipose-derived stem cells isolated from mediastinal tissue during cardiac surgery

Amit N. Patel, James Yockman, Vanessa Vargas, David A. Bull

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Mesenchymal stem cells have been isolated from various adult human tissues and are valuable for not only therapeutic applications but for the study of tissue homeostasis and disease progression. Subcutaneous adipose depots have been shown to contain large amounts of stem cells. There is little information that has been reported to date describing the isolation and characterization of mesenchymal stem cells from visceral adipose tissue. In this study, we describe a mesenchymal stem cell population isolated from mediastinal adipose depots. The cells express CD44, CD105, CD166, and CD90 and are negative for hematopoietic markers CD34, CD45, and HLA-DR. In addition, the cells have a multilineage potential, with the ability to differentiate into adipogenic, osteogenic, and chondrogenic cell types. The biological function of visceral adipose tissue remains largely unknown and uncharacterized. However, the proximity of adipose tissue to the heart suggests a potential role in the pathogenesis of cardiovascular disease in obesity. In addition, with the ability of fat to regulate metabolic activity in humans, this novel stem cell source may be useful to further study the mechanisms involved in metabolic disorders.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
JournalCell transplantation
Volume22
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Adipose
  • Mediastinal
  • Metabolic
  • Stem cells
  • Surgery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Fingerprint

Dive into the research topics of 'Putative population of adipose-derived stem cells isolated from mediastinal tissue during cardiac surgery'. Together they form a unique fingerprint.

Cite this