Purine metabolism in pigs and humans and its implications for xenotransplantation

R. T. Smolenski; Z. Khalpey; A. Yuen; H. Dziewit; E. M. Slominska; T. Borkowski; M. Zdunek; Z. Kochan; J. Karbowska; M. Lavitrano; M. H. Yacoub

doi:10.1081/NCN-59701

Purine metabolism in pigs and humans and its implications for xenotransplantation

R. T. Smolenski, Z. Khalpey, A. Yuen, H. Dziewit, E. M. Slominska, T. Borkowski, M. Zdunek, Z. Kochan, J. Karbowska, M. Lavitrano, M. H. Yacoub

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We compared concentrations of nucleotide substrates and activities of enzymes of nucleotide metabolism in pig and human blood, heart, and kidney. The most important difference was lower ecto-5′-nucleotidase (E5′N) activity in both pig hearts and kidney. Furthermore, higher hypoxanthine, inosine, adenine, and uracil, but lower undine and uric acid concentrations were observed in pig blood as compared to human. A twofold increase in UTP concentration has been observed in pig hearts following 4 h perfusion with human blood. Purine metabolism is an important target for genetic and pharmacological manipulation during xenotransplantations.

Original language	English (US)
Pages (from-to)	263-266
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	24
Issue number	4
DOIs	https://doi.org/10.1081/NCN-59701
State	Published - 2005
Externally published	Yes

Keywords

ATP
Ecto-5′-Nucleotidase
Nucleotides
Purine Metabolites
UTP
Xenotransplantation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Genetics

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10.1081/NCN-59701

Cite this

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title = "Purine metabolism in pigs and humans and its implications for xenotransplantation",

abstract = "We compared concentrations of nucleotide substrates and activities of enzymes of nucleotide metabolism in pig and human blood, heart, and kidney. The most important difference was lower ecto-5′-nucleotidase (E5′N) activity in both pig hearts and kidney. Furthermore, higher hypoxanthine, inosine, adenine, and uracil, but lower undine and uric acid concentrations were observed in pig blood as compared to human. A twofold increase in UTP concentration has been observed in pig hearts following 4 h perfusion with human blood. Purine metabolism is an important target for genetic and pharmacological manipulation during xenotransplantations.",

keywords = "ATP, Ecto-5′-Nucleotidase, Nucleotides, Purine Metabolites, UTP, Xenotransplantation",

author = "Smolenski, {R. T.} and Z. Khalpey and A. Yuen and H. Dziewit and Slominska, {E. M.} and T. Borkowski and M. Zdunek and Z. Kochan and J. Karbowska and M. Lavitrano and Yacoub, {M. H.}",

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doi = "10.1081/NCN-59701",

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pages = "263--266",

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TY - JOUR

T1 - Purine metabolism in pigs and humans and its implications for xenotransplantation

AU - Smolenski, R. T.

AU - Khalpey, Z.

AU - Yuen, A.

AU - Dziewit, H.

AU - Slominska, E. M.

AU - Borkowski, T.

AU - Zdunek, M.

AU - Kochan, Z.

AU - Karbowska, J.

AU - Lavitrano, M.

AU - Yacoub, M. H.

PY - 2005

Y1 - 2005

N2 - We compared concentrations of nucleotide substrates and activities of enzymes of nucleotide metabolism in pig and human blood, heart, and kidney. The most important difference was lower ecto-5′-nucleotidase (E5′N) activity in both pig hearts and kidney. Furthermore, higher hypoxanthine, inosine, adenine, and uracil, but lower undine and uric acid concentrations were observed in pig blood as compared to human. A twofold increase in UTP concentration has been observed in pig hearts following 4 h perfusion with human blood. Purine metabolism is an important target for genetic and pharmacological manipulation during xenotransplantations.

AB - We compared concentrations of nucleotide substrates and activities of enzymes of nucleotide metabolism in pig and human blood, heart, and kidney. The most important difference was lower ecto-5′-nucleotidase (E5′N) activity in both pig hearts and kidney. Furthermore, higher hypoxanthine, inosine, adenine, and uracil, but lower undine and uric acid concentrations were observed in pig blood as compared to human. A twofold increase in UTP concentration has been observed in pig hearts following 4 h perfusion with human blood. Purine metabolism is an important target for genetic and pharmacological manipulation during xenotransplantations.

KW - ATP

KW - Ecto-5′-Nucleotidase

KW - Nucleotides

KW - Purine Metabolites

KW - UTP

KW - Xenotransplantation

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DO - 10.1081/NCN-59701

M3 - Article

C2 - 16021912

AN - SCOPUS:22044436408

SN - 1525-7770

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JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 4

ER -

Purine metabolism in pigs and humans and its implications for xenotransplantation

Abstract

Keywords

ASJC Scopus subject areas

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