Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy

Yash Shashank Vakilna; Ganne Chaitanya; Muhammad Ubaid Hafeez; Adeel Ilyas; Manojkumar Saranathan; Jay Gavvala; Nitin Tandon; Sandipan Pati

doi:10.1002/acn3.51815

Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy

Yash Shashank Vakilna
, Ganne Chaitanya
, Muhammad Ubaid Hafeez
, Adeel Ilyas
, Manojkumar Saranathan
, Jay Gavvala
, Nitin Tandon
, Sandipan Pati

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real-time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.

Original language	English (US)
Pages (from-to)	1254-1259
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	10
Issue number	7
DOIs	https://doi.org/10.1002/acn3.51815
State	Published - Jul 2023
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1002/acn3.51815

Cite this

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title = "Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy",

abstract = "Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real-time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.",

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AU - Vakilna, Yash Shashank

AU - Chaitanya, Ganne

AU - Hafeez, Muhammad Ubaid

AU - Ilyas, Adeel

AU - Saranathan, Manojkumar

AU - Gavvala, Jay

AU - Tandon, Nitin

AU - Pati, Sandipan

PY - 2023/7

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Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy

Abstract

ASJC Scopus subject areas

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