Pulmonary histoplasmosis

Chadi A. Hage; L. Joseph Wheat; James Loyd; Stephen D. Allen; Deborah Blue; Kenneth S. Knox

doi:10.1055/s-2008-1063854

Pulmonary histoplasmosis

Chadi A. Hage, L. Joseph Wheat, James Loyd, Stephen D. Allen, Deborah Blue, Kenneth S. Knox

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Pulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment. The reader is referred to the earlier review for subjects not fully addressed herein. Knowledge of the utility of serological testing is essential, particularly when antigen tests and cultures are negative. Antigen testing is most useful in patients with more diffuse pulmonary involvement and those with progressive disseminated disease due to the high fungal burden. Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes.

Original language	English (US)
Pages (from-to)	151-165
Number of pages	15
Journal	Seminars in Respiratory and Critical Care Medicine
Volume	29
Issue number	2
DOIs	https://doi.org/10.1055/s-2008-1063854
State	Published - Apr 2008

Keywords

Antigen
Diagnosis
Histoplasmosis
Serology
Treatment

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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10.1055/s-2008-1063854

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title = "Pulmonary histoplasmosis",

abstract = "Pulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment. The reader is referred to the earlier review for subjects not fully addressed herein. Knowledge of the utility of serological testing is essential, particularly when antigen tests and cultures are negative. Antigen testing is most useful in patients with more diffuse pulmonary involvement and those with progressive disseminated disease due to the high fungal burden. Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes.",

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T1 - Pulmonary histoplasmosis

AU - Hage, Chadi A.

AU - Wheat, L. Joseph

AU - Loyd, James

AU - Allen, Stephen D.

AU - Blue, Deborah

AU - Knox, Kenneth S.

PY - 2008/4

Y1 - 2008/4

N2 - Pulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment. The reader is referred to the earlier review for subjects not fully addressed herein. Knowledge of the utility of serological testing is essential, particularly when antigen tests and cultures are negative. Antigen testing is most useful in patients with more diffuse pulmonary involvement and those with progressive disseminated disease due to the high fungal burden. Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes.

AB - Pulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment. The reader is referred to the earlier review for subjects not fully addressed herein. Knowledge of the utility of serological testing is essential, particularly when antigen tests and cultures are negative. Antigen testing is most useful in patients with more diffuse pulmonary involvement and those with progressive disseminated disease due to the high fungal burden. Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes.

KW - Antigen

KW - Diagnosis

KW - Histoplasmosis

KW - Serology

KW - Treatment

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Pulmonary histoplasmosis

Abstract

Keywords

ASJC Scopus subject areas

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