TY - JOUR
T1 - Pulmonary artery hypertension in severe aortic stenosis
T2 - Incidence and mechanism
AU - Silver, Kevin
AU - Aurigemma, Gerard
AU - Krendel, Steven
AU - Barry, Nicole
AU - Ockene, Ira
AU - Alpert, Joseph
N1 - Funding Information:
From the Cardiovascular Division, Department of Medicine, University of Masaachusetta Medical Center, Worcester. Supported, in part, by grant 6-327’79, Biomedical Research Support Grant Program, National Institute of Health, Bethesda, Md. Received for publication June 17, 1992; accepted Aug. 3, 1992. Reprint requests: Gerard Aurigemma, MD, Cardiology Division, University of Massachusetts Medical Center, 56 Lake Avenue North, Worcester, MA, 01655. 411142142
PY - 1993/1
Y1 - 1993/1
N2 - We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH (pulmonary artery systolic pressure >50 mm Hg); group 2 comprised 32 patients (71%) without PAH. Group 1 patients had a higher incidence of congestive heart failure, a lower left ventricular ejection fraction and cardiac index, and more mitral regurgitation as compared with group 2 patients. Of the 13 group 1 patients, 8 had a transpulmonary gradient (pulmonary artery mean pressure - pulmonary capillary wedge pressure) ≥10 mm Hg, consistent with reactive PAH. We conclude that PAH frequently accompanies aortic stenosis and is often reactive.
AB - We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH (pulmonary artery systolic pressure >50 mm Hg); group 2 comprised 32 patients (71%) without PAH. Group 1 patients had a higher incidence of congestive heart failure, a lower left ventricular ejection fraction and cardiac index, and more mitral regurgitation as compared with group 2 patients. Of the 13 group 1 patients, 8 had a transpulmonary gradient (pulmonary artery mean pressure - pulmonary capillary wedge pressure) ≥10 mm Hg, consistent with reactive PAH. We conclude that PAH frequently accompanies aortic stenosis and is often reactive.
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U2 - 10.1016/0002-8703(93)90067-J
DO - 10.1016/0002-8703(93)90067-J
M3 - Article
C2 - 8417510
AN - SCOPUS:0027510159
SN - 0002-8703
VL - 125
SP - 146
EP - 150
JO - American Heart Journal
JF - American Heart Journal
IS - 1
ER -