Pulmonary artery hypertension in severe aortic stenosis: Incidence and mechanism

Kevin Silver, Gerard Aurigemma, Steven Krendel, Nicole Barry, Ira Ockene, Joseph Alpert

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH (pulmonary artery systolic pressure >50 mm Hg); group 2 comprised 32 patients (71%) without PAH. Group 1 patients had a higher incidence of congestive heart failure, a lower left ventricular ejection fraction and cardiac index, and more mitral regurgitation as compared with group 2 patients. Of the 13 group 1 patients, 8 had a transpulmonary gradient (pulmonary artery mean pressure - pulmonary capillary wedge pressure) ≥10 mm Hg, consistent with reactive PAH. We conclude that PAH frequently accompanies aortic stenosis and is often reactive.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalAmerican Heart Journal
Issue number1
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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