Pseudosarcomatous changes in inflammatory pseudopolyps of the colon

J. Jessurun, S. H. Paplanus, R. B. Nagle, S. R. Hamilton, J. H. Yardley, M. Tripp

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The occurrence of pseudomalignant changes in biopsy specimens from two patients with ulcerative colitis and pseudopolyposis is described. One lesion was characterized by the proliferation of large ganglion cell-like cells, similar to those observed in proliferative faciitis. Ultrastructural and immunohistochemical findings supported a fibroblastic origin. Biopsy specimens of an inflammatory pseudopolyp from the second patient showed proliferation of oval to spindle cells that were initially interpreted as a possible neoplasm. The site of origin and reactive nature of this lesion became apparent on a subsequent polypectomy specimen. Attention is called to the occurrence of pseudosarcomatous changes in inflammatory pseudopolyps of the gastrointestinal tract that may lead to an erroneous diagnosis of malignancy.

Original languageEnglish (US)
Pages (from-to)833-836
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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