Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis

Rihab Bouchareb, Sandra Guauque-Olarte, Justin Snider, Devyn Zaminski, Anelechi Anyanwu, Paul Stelzer, Djamel Lebeche

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.

Original languageEnglish (US)
Pages (from-to)25-39
Number of pages15
JournalJACC: Basic to Translational Science
Volume6
Issue number1
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • ECM
  • RNA-Seq
  • aortic stenosis
  • calcified aortic valves
  • metabolism
  • proteomics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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