Protein-only inheritance in yeast: Something to get [PSI+]-ched about

Tricia R. Serio, Susan L. Lindquist

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Recent work suggests that two unrelated phenotypes, [PSI+] and [URE3], in the yeast Saccharomyces cerevisiae are transmitted by non-covalent changes in the physical states of their protein determinants, Sup35p and Ure2p, rather than by changes in the genes that encode these proteins. The mechanism by which alternative protein states are self-propagating is the key to understanding how proteins function as elements of epigenetic inheritance. Here, we focus on recent molecular-genetic analysis of the inheritance of the [PSI+] factor of S. cerevisiae. Insights into this process might be extendable to a group of mammalian diseases (the amyloidoses), which are also believed to be a manifestation of self-perpetuating changes in protein conformation.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalTrends in Cell Biology
Issue number3
StatePublished - Mar 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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