Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease

Melissa Furlong, Caroline M. Tanner, Samuel M. Goldman, Grace S. Bhudhikanok, Aaron Blair, Anabel Chade, Kathleen Comyns, Jane A. Hoppin, Meike Kasten, Monica Korell, J. William Langston, Connie Marras, Cheryl Meng, Marie Richards, G. Webster Ross, David M. Umbach, Dale P. Sandler, Freya Kamel

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Pesticides have been associated with Parkinson's disease (PD), and protective gloves and workplace hygiene can reduce pesticide exposure. We assessed whether use of gloves and workplace hygiene modified associations between pesticides and PD. The Farming and Movement Evaluation (FAME) study is a nested case-control study within the Agricultural Health Study. Use of protective gloves, other PPE, and hygiene practices were determined by questionnaire (69 cases and 237 controls were included). We considered interactions of gloves and hygiene with ever-use of pesticides for all pesticides with ≥. 5 exposed and unexposed cases and controls in each glove-use stratum (paraquat, permethrin, rotenone, and trifluralin). 61% of respondents consistently used protective gloves and 87% consistently used ≥. 2 hygiene practices. Protective glove use modified the associations of paraquat and permethrin with PD: neither pesticide was associated with PD among protective glove users, while both pesticides were associated with PD among non-users (paraquat OR 3.9 [95% CI 1.3, 11.7], interaction p = 0.15; permethrin OR 4.3 [95% CI 1.2, 15.6] interaction p = 0.05). Rotenone was associated with PD regardless of glove use. Trifluralin was associated with PD among participants who used <. 2 hygiene practices (OR 5.5 [95% CI 1.1, 27.1]) but was not associated with PD among participants who used 2 or more practices (interaction p = 0.02). Although sample size was limited in the FAME study, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and PD and may reduce risk of PD associated with certain pesticides.

Original languageEnglish (US)
Pages (from-to)144-150
Number of pages7
JournalEnvironment international
Volume75
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Keywords

  • Movement disorders
  • Neurodegenerative diseases
  • Parkinson's disease
  • Personal protective equipment
  • Pesticides

ASJC Scopus subject areas

  • Environmental Science(all)

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