Abstract
Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague-Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60 mg/kg 3×per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy X-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by microcomputerized tomography (μCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor.
Original language | English (US) |
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Pages (from-to) | 9498-9504 |
Number of pages | 7 |
Journal | Journal of agricultural and food chemistry |
Volume | 58 |
Issue number | 17 |
DOIs | |
State | Published - Sep 8 2010 |
Keywords
- Curcuma longa L.
- Turmeric
- bone mineral density
- bone μCT
- curcuminoids
- ovariectomy
ASJC Scopus subject areas
- General Chemistry
- General Agricultural and Biological Sciences