Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA

Lisa Shubitz; Tao Peng; Robert Perrill; Julie Simons; Kris Orsborn; John N. Galgiani

doi:10.1128/IAI.70.6.3287-3289.2002

Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA

Lisa Shubitz, Tao Peng, Robert Perrill, Julie Simons, Kris Orsborn, John N. Galgiani

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.

Original language	English (US)
Pages (from-to)	3287-3289
Number of pages	3
Journal	Infection and Immunity
Volume	70
Issue number	6
DOIs	https://doi.org/10.1128/IAI.70.6.3287-3289.2002
State	Published - 2002

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.70.6.3287-3289.2002

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abstract = "Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.",

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AU - Shubitz, Lisa

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AU - Perrill, Robert

AU - Simons, Julie

AU - Orsborn, Kris

AU - Galgiani, John N.

PY - 2002

Y1 - 2002

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AB - Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.

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Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA

Abstract

ASJC Scopus subject areas

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