Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023

Leora R. Feldstein; Jasmine Ruffin; Ryan Wiegand; Lauren Grant; Tara M. Babu; Melissa Briggs-Hagen; Jefferey L. Burgess; Alberto J. Caban-Martinez; Helen Y. Chu; Katherine D. Ellingson; Janet A. Englund; Kurt T. Hegmann; Zuha Jeddy; Jennifer Kuntz; Adam S. Lauring; Karen Lutrick; Emily T. Martin; Clare Mathenge; Jennifer Meece; Claire M. Midgley; Arnold S. Monto; Allison L. Naleway; Gabriella Newes-Adeyi; Leah Odame-Bamfo; Lauren E.W. Olsho; Andrew L. Phillips; Ramona P. Rai; Sharon Saydah; Ning Smith; Harmony Tyner; Molly Vaughan; Ana A. Weil; Sarang K. Yoon; Amadea Britton; Manjusha Gaglani

doi:10.1093/jpids/piae121

Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023

Leora R. Feldstein, Jasmine Ruffin, Ryan Wiegand, Lauren Grant, Tara M. Babu, Melissa Briggs-Hagen, Jefferey L. Burgess, Alberto J. Caban-Martinez, Helen Y. Chu, Katherine D. Ellingson, Janet A. Englund, Kurt T. Hegmann, Zuha Jeddy, Jennifer Kuntz, Adam S. Lauring, Karen Lutrick, Emily T. Martin, Clare Mathenge, Jennifer Meece, Claire M. MidgleyArnold S. Monto, Allison L. Naleway, Gabriella Newes-Adeyi, Leah Odame-Bamfo, Lauren E.W. Olsho, Andrew L. Phillips, Ramona P. Rai, Sharon Saydah, Ning Smith, Harmony Tyner, Molly Vaughan, Ana A. Weil, Sarang K. Yoon, Amadea Britton, Manjusha Gaglani

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.

Original language	English (US)
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	14
Issue number	1
DOIs	https://doi.org/10.1093/jpids/piae121
State	Published - Jan 1 2025

Keywords

COVID-19
SARSCoV-2
children
prior infection
vaccination

ASJC Scopus subject areas

General Medicine

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10.1093/jpids/piae121

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Feldstein, L. R., Ruffin, J., Wiegand, R., Grant, L., Babu, T. M., Briggs-Hagen, M., Burgess, J. L., Caban-Martinez, A. J., Chu, H. Y., Ellingson, K. D., Englund, J. A., Hegmann, K. T., Jeddy, Z., Kuntz, J., Lauring, A. S., Lutrick, K., Martin, E. T., Mathenge, C., Meece, J., ... Gaglani, M. (2025). Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023. Journal of the Pediatric Infectious Diseases Society, 14(1). https://doi.org/10.1093/jpids/piae121

Feldstein, LR, Ruffin, J, Wiegand, R, Grant, L, Babu, TM, Briggs-Hagen, M, Burgess, JL, Caban-Martinez, AJ, Chu, HY, Ellingson, KD, Englund, JA, Hegmann, KT, Jeddy, Z, Kuntz, J, Lauring, AS, Lutrick, K, Martin, ET, Mathenge, C, Meece, J, Midgley, CM, Monto, AS, Naleway, AL, Newes-Adeyi, G, Odame-Bamfo, L, Olsho, LEW, Phillips, AL, Rai, RP, Saydah, S, Smith, N, Tyner, H, Vaughan, M, Weil, AA, Yoon, SK, Britton, A & Gaglani, M 2025, 'Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023', Journal of the Pediatric Infectious Diseases Society, vol. 14, no. 1. https://doi.org/10.1093/jpids/piae121

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title = "Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023",

abstract = "To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in na{\"i}ve young children.",

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author = "Feldstein, \{Leora R.\} and Jasmine Ruffin and Ryan Wiegand and Lauren Grant and Babu, \{Tara M.\} and Melissa Briggs-Hagen and Burgess, \{Jefferey L.\} and Caban-Martinez, \{Alberto J.\} and Chu, \{Helen Y.\} and Ellingson, \{Katherine D.\} and Englund, \{Janet A.\} and Hegmann, \{Kurt T.\} and Zuha Jeddy and Jennifer Kuntz and Lauring, \{Adam S.\} and Karen Lutrick and Martin, \{Emily T.\} and Clare Mathenge and Jennifer Meece and Midgley, \{Claire M.\} and Monto, \{Arnold S.\} and Naleway, \{Allison L.\} and Gabriella Newes-Adeyi and Leah Odame-Bamfo and Olsho, \{Lauren E.W.\} and Phillips, \{Andrew L.\} and Rai, \{Ramona P.\} and Sharon Saydah and Ning Smith and Harmony Tyner and Molly Vaughan and Weil, \{Ana A.\} and Yoon, \{Sarang K.\} and Amadea Britton and Manjusha Gaglani",

year = "2025",

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doi = "10.1093/jpids/piae121",

language = "English (US)",

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AU - Wiegand, Ryan

AU - Grant, Lauren

AU - Babu, Tara M.

AU - Briggs-Hagen, Melissa

AU - Burgess, Jefferey L.

AU - Caban-Martinez, Alberto J.

AU - Chu, Helen Y.

AU - Ellingson, Katherine D.

AU - Englund, Janet A.

AU - Hegmann, Kurt T.

AU - Jeddy, Zuha

AU - Kuntz, Jennifer

AU - Lauring, Adam S.

AU - Lutrick, Karen

AU - Martin, Emily T.

AU - Mathenge, Clare

AU - Meece, Jennifer

AU - Midgley, Claire M.

AU - Monto, Arnold S.

AU - Naleway, Allison L.

AU - Newes-Adeyi, Gabriella

AU - Odame-Bamfo, Leah

AU - Olsho, Lauren E.W.

AU - Phillips, Andrew L.

AU - Rai, Ramona P.

AU - Saydah, Sharon

AU - Smith, Ning

AU - Tyner, Harmony

AU - Vaughan, Molly

AU - Weil, Ana A.

AU - Yoon, Sarang K.

AU - Britton, Amadea

AU - Gaglani, Manjusha

PY - 2025/1/1

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AB - To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.

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KW - SARSCoV-2

KW - children

KW - prior infection

KW - vaccination

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Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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