Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023

Leora R. Feldstein; Jasmine Ruffin; Ryan Wiegand; Lauren Grant; Tara M. Babu; Melissa Briggs-Hagen; Jefferey L. Burgess; Alberto J. Caban-Martinez; Helen Y. Chu; Katherine D. Ellingson; Janet A. Englund; Kurt T. Hegmann; Zuha Jeddy; Jennifer Kuntz; Adam S. Lauring; Karen Lutrick; Emily T. Martin; Clare Mathenge; Jennifer Meece; Claire M. Midgley; Arnold S. Monto; Allison L. Naleway; Gabriella Newes-Adeyi; Leah Odame-Bamfo; Lauren E.W. Olsho; Andrew L. Phillips; Ramona P. Rai; Sharon Saydah; Ning Smith; Harmony Tyner; Molly Vaughan; Ana A. Weil; Sarang K. Yoon; Amadea Britton; Manjusha Gaglani

doi:10.1093/jpids/piae121

Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023

Leora R. Feldstein
, Jasmine Ruffin
, Ryan Wiegand
, Lauren Grant
, Tara M. Babu
, Melissa Briggs-Hagen
, Jefferey L. Burgess
, Alberto J. Caban-Martinez
, Helen Y. Chu
, Katherine D. Ellingson
, Janet A. Englund
, Kurt T. Hegmann
, Zuha Jeddy
, Jennifer Kuntz
, Adam S. Lauring
, Karen Lutrick
, Emily T. Martin
, Clare Mathenge
, Jennifer Meece
, Claire M. Midgley

Arnold S. Monto, Allison L. Naleway, Gabriella Newes-Adeyi, Leah Odame-Bamfo, Lauren E.W. Olsho, Andrew L. Phillips, Ramona P. Rai, Sharon Saydah, Ning Smith, Harmony Tyner, Molly Vaughan, Ana A. Weil, Sarang K. Yoon, Amadea Britton, Manjusha Gaglani

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.

Original language	English (US)
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	14
Issue number	1
DOIs	https://doi.org/10.1093/jpids/piae121
State	Published - Jan 1 2025

Keywords

COVID-19
SARSCoV-2
children
prior infection
vaccination

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases

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10.1093/jpids/piae121

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Feldstein, L. R., Ruffin, J., Wiegand, R., Grant, L., Babu, T. M., Briggs-Hagen, M., Burgess, J. L., Caban-Martinez, A. J., Chu, H. Y., Ellingson, K. D., Englund, J. A., Hegmann, K. T., Jeddy, Z., Kuntz, J., Lauring, A. S., Lutrick, K., Martin, E. T., Mathenge, C., Meece, J., ... Gaglani, M. (2025). Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023. Journal of the Pediatric Infectious Diseases Society, 14(1). https://doi.org/10.1093/jpids/piae121

Feldstein, LR, Ruffin, J, Wiegand, R, Grant, L, Babu, TM, Briggs-Hagen, M, Burgess, JL, Caban-Martinez, AJ, Chu, HY, Ellingson, KD, Englund, JA, Hegmann, KT, Jeddy, Z, Kuntz, J, Lauring, AS, Lutrick, K, Martin, ET, Mathenge, C, Meece, J, Midgley, CM, Monto, AS, Naleway, AL, Newes-Adeyi, G, Odame-Bamfo, L, Olsho, LEW, Phillips, AL, Rai, RP, Saydah, S, Smith, N, Tyner, H, Vaughan, M, Weil, AA, Yoon, SK, Britton, A & Gaglani, M 2025, 'Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023', Journal of the Pediatric Infectious Diseases Society, vol. 14, no. 1. https://doi.org/10.1093/jpids/piae121

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title = "Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months{\textendash}4 Years, United States, September 2022{\textendash}April 2023",

abstract = "To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in na{\"i}ve young children.",

keywords = "COVID-19, SARSCoV-2, children, prior infection, vaccination",

author = "Feldstein, \{Leora R.\} and Jasmine Ruffin and Ryan Wiegand and Lauren Grant and Babu, \{Tara M.\} and Melissa Briggs-Hagen and Burgess, \{Jefferey L.\} and Caban-Martinez, \{Alberto J.\} and Chu, \{Helen Y.\} and Ellingson, \{Katherine D.\} and Englund, \{Janet A.\} and Hegmann, \{Kurt T.\} and Zuha Jeddy and Jennifer Kuntz and Lauring, \{Adam S.\} and Karen Lutrick and Martin, \{Emily T.\} and Clare Mathenge and Jennifer Meece and Midgley, \{Claire M.\} and Monto, \{Arnold S.\} and Naleway, \{Allison L.\} and Gabriella Newes-Adeyi and Leah Odame-Bamfo and Olsho, \{Lauren E.W.\} and Phillips, \{Andrew L.\} and Rai, \{Ramona P.\} and Sharon Saydah and Ning Smith and Harmony Tyner and Molly Vaughan and Weil, \{Ana A.\} and Yoon, \{Sarang K.\} and Amadea Britton and Manjusha Gaglani",

year = "2025",

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doi = "10.1093/jpids/piae121",

language = "English (US)",

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AU - Wiegand, Ryan

AU - Grant, Lauren

AU - Babu, Tara M.

AU - Briggs-Hagen, Melissa

AU - Burgess, Jefferey L.

AU - Caban-Martinez, Alberto J.

AU - Chu, Helen Y.

AU - Ellingson, Katherine D.

AU - Englund, Janet A.

AU - Hegmann, Kurt T.

AU - Jeddy, Zuha

AU - Kuntz, Jennifer

AU - Lauring, Adam S.

AU - Lutrick, Karen

AU - Martin, Emily T.

AU - Mathenge, Clare

AU - Meece, Jennifer

AU - Midgley, Claire M.

AU - Monto, Arnold S.

AU - Naleway, Allison L.

AU - Newes-Adeyi, Gabriella

AU - Odame-Bamfo, Leah

AU - Olsho, Lauren E.W.

AU - Phillips, Andrew L.

AU - Rai, Ramona P.

AU - Saydah, Sharon

AU - Smith, Ning

AU - Tyner, Harmony

AU - Vaughan, Molly

AU - Weil, Ana A.

AU - Yoon, Sarang K.

AU - Britton, Amadea

AU - Gaglani, Manjusha

PY - 2025/1/1

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AB - To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.

KW - COVID-19

KW - SARSCoV-2

KW - children

KW - prior infection

KW - vaccination

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VL - 14

JO - Journal of the Pediatric Infectious Diseases Society

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ER -

Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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