Protection against anthramycin-induced toxicity in mice by coenzyme Q10

W. C. Lubawy; R. A. Dallam; L. H. Hurley

Protection against anthramycin-induced toxicity in mice by coenzyme Q₁₀

W. C. Lubawy, R. A. Dallam, L. H. Hurley

Research output: Contribution to journal › Article › peer-review

Abstract

Pretreatment of Swiss Webster mice with coenzyme Q₁₀ (CoQ) markedly reduced the lethality of the antitumor antibiotic anthramycin as well as its ability to decrease ventricular weights. In tumor-bearing mice CoQ pretreatment did not produce any consistent alteration of radioactivity levels in blood, heart, tumor, lungs, kidneys, liver, muscles, brain, or spleen after [15-³H]anthramycin administration. Gross alterations in anthramycin distribution is probably not the mechanism by which CoQ alters the cardiotoxicity and lethality of anthramycin.

Original language	English (US)
Pages (from-to)	105-109
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	64
Issue number	1
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{461b7ba511414410834dd371ddf147c0,

title = "Protection against anthramycin-induced toxicity in mice by coenzyme Q10",

abstract = "Pretreatment of Swiss Webster mice with coenzyme Q10 (CoQ) markedly reduced the lethality of the antitumor antibiotic anthramycin as well as its ability to decrease ventricular weights. In tumor-bearing mice CoQ pretreatment did not produce any consistent alteration of radioactivity levels in blood, heart, tumor, lungs, kidneys, liver, muscles, brain, or spleen after [15-3H]anthramycin administration. Gross alterations in anthramycin distribution is probably not the mechanism by which CoQ alters the cardiotoxicity and lethality of anthramycin.",

author = "Lubawy, {W. C.} and Dallam, {R. A.} and Hurley, {L. H.}",

year = "1980",

language = "English (US)",

volume = "64",

pages = "105--109",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Protection against anthramycin-induced toxicity in mice by coenzyme Q10

AU - Lubawy, W. C.

AU - Dallam, R. A.

AU - Hurley, L. H.

PY - 1980

Y1 - 1980

N2 - Pretreatment of Swiss Webster mice with coenzyme Q10 (CoQ) markedly reduced the lethality of the antitumor antibiotic anthramycin as well as its ability to decrease ventricular weights. In tumor-bearing mice CoQ pretreatment did not produce any consistent alteration of radioactivity levels in blood, heart, tumor, lungs, kidneys, liver, muscles, brain, or spleen after [15-3H]anthramycin administration. Gross alterations in anthramycin distribution is probably not the mechanism by which CoQ alters the cardiotoxicity and lethality of anthramycin.

AB - Pretreatment of Swiss Webster mice with coenzyme Q10 (CoQ) markedly reduced the lethality of the antitumor antibiotic anthramycin as well as its ability to decrease ventricular weights. In tumor-bearing mice CoQ pretreatment did not produce any consistent alteration of radioactivity levels in blood, heart, tumor, lungs, kidneys, liver, muscles, brain, or spleen after [15-3H]anthramycin administration. Gross alterations in anthramycin distribution is probably not the mechanism by which CoQ alters the cardiotoxicity and lethality of anthramycin.

UR - http://www.scopus.com/inward/record.url?scp=0018923169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018923169&partnerID=8YFLogxK

M3 - Article

C2 - 6928034

AN - SCOPUS:0018923169

SN - 0027-8874

VL - 64

SP - 105

EP - 109

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 1

ER -

Protection against anthramycin-induced toxicity in mice by coenzyme Q₁₀

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this