TY - JOUR
T1 - Prostanoid receptors and phosphatidylinositol 3-kinase
T2 - A pathway to cancer?
AU - Fujino, Hiromichi
AU - Regan, John W.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - The significance of receptor heterogeneity has, in many cases, been unclear, particularly in the case of closely related receptor subtypes that are activated by the same endogenous ligands and appear to signal through the same second messenger pathways. In this article, recent studies of the EP and FP prostanoid receptors are reviewed, showing that receptor subtypes previously thought to activate the same signaling pathways, in fact, differ through novel interactions with phosphatidylinositol 3-kinase and activation of nuclear signaling pathways. These findings might be applicable to other families of G-protein-coupled receptors and have implications in cancer and other diseases.
AB - The significance of receptor heterogeneity has, in many cases, been unclear, particularly in the case of closely related receptor subtypes that are activated by the same endogenous ligands and appear to signal through the same second messenger pathways. In this article, recent studies of the EP and FP prostanoid receptors are reviewed, showing that receptor subtypes previously thought to activate the same signaling pathways, in fact, differ through novel interactions with phosphatidylinositol 3-kinase and activation of nuclear signaling pathways. These findings might be applicable to other families of G-protein-coupled receptors and have implications in cancer and other diseases.
UR - http://www.scopus.com/inward/record.url?scp=0042734625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042734625&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(03)00162-7
DO - 10.1016/S0165-6147(03)00162-7
M3 - Article
C2 - 12871665
AN - SCOPUS:0042734625
SN - 0165-6147
VL - 24
SP - 335
EP - 340
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 7
ER -