Prostaglandins and the pulmonary circulation

Joseph S. Alpert; Florence W. Haynes; Paul A. Knutson; James E. Dalen; Lewis Dexter

doi:10.1016/0090-6980(73)90002-6

Prostaglandins and the pulmonary circulation

Joseph S. Alpert, Florence W. Haynes, Paul A. Knutson, James E. Dalen, Lewis Dexter

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Prostaglandins (PG) E₁, E₂, F_2^α, and A₁ were infused into 15 normal mongrel dogs at doses varying from .04 - 6.0 μg/kg/min. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; pulmonary blood volume and cardiac output were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. PGE₁ caused mild active vasodilatation while PGF_2^α resulted in milactive vasoconstriction in the lung. PGE₂ and PGA₁ caused passive shrinkage of the pulmonary vascular bed secondary to a shift of blood to the peripheral circulation.

Original language	English (US)
Pages (from-to)	759-765
Number of pages	7
Journal	Prostaglandins
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/0090-6980(73)90002-6
State	Published - Jun 1973
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

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title = "Prostaglandins and the pulmonary circulation",

abstract = "Prostaglandins (PG) E1, E2, F2α, and A1 were infused into 15 normal mongrel dogs at doses varying from .04 - 6.0 μg/kg/min. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; pulmonary blood volume and cardiac output were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. PGE1 caused mild active vasodilatation while PGF2α resulted in milactive vasoconstriction in the lung. PGE2 and PGA1 caused passive shrinkage of the pulmonary vascular bed secondary to a shift of blood to the peripheral circulation.",

author = "Alpert, {Joseph S.} and Haynes, {Florence W.} and Knutson, {Paul A.} and Dalen, {James E.} and Lewis Dexter",

note = "Funding Information: This work was done during the tenure of a research fellowship from the Cape and Island Chapter of the Massachusetts Heart Association #1080-F Funding Information: This work was also supported in part by Grant HL12439-03 from the National Institutes of Health, United States Public Health Services",

year = "1973",

month = jun,

doi = "10.1016/0090-6980(73)90002-6",

language = "English (US)",

volume = "3",

pages = "759--765",

journal = "Prostaglandins",

issn = "0090-6980",

publisher = "Elsevier B.V.",

number = "6",

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TY - JOUR

T1 - Prostaglandins and the pulmonary circulation

AU - Alpert, Joseph S.

AU - Haynes, Florence W.

AU - Knutson, Paul A.

AU - Dalen, James E.

AU - Dexter, Lewis

N1 - Funding Information: This work was done during the tenure of a research fellowship from the Cape and Island Chapter of the Massachusetts Heart Association #1080-F Funding Information: This work was also supported in part by Grant HL12439-03 from the National Institutes of Health, United States Public Health Services

PY - 1973/6

Y1 - 1973/6

N2 - Prostaglandins (PG) E1, E2, F2α, and A1 were infused into 15 normal mongrel dogs at doses varying from .04 - 6.0 μg/kg/min. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; pulmonary blood volume and cardiac output were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. PGE1 caused mild active vasodilatation while PGF2α resulted in milactive vasoconstriction in the lung. PGE2 and PGA1 caused passive shrinkage of the pulmonary vascular bed secondary to a shift of blood to the peripheral circulation.

AB - Prostaglandins (PG) E1, E2, F2α, and A1 were infused into 15 normal mongrel dogs at doses varying from .04 - 6.0 μg/kg/min. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; pulmonary blood volume and cardiac output were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. PGE1 caused mild active vasodilatation while PGF2α resulted in milactive vasoconstriction in the lung. PGE2 and PGA1 caused passive shrinkage of the pulmonary vascular bed secondary to a shift of blood to the peripheral circulation.

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JO - Prostaglandins

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Prostaglandins and the pulmonary circulation

Abstract

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