Prostaglandin F2α stimulation of cyclooxygenase-2 promoter activity by the FPB prostanoid receptor

Hiromichi Fujino; John W. Regan

doi:10.1016/S0014-2999(03)01485-7

Prostaglandin F_2α stimulation of cyclooxygenase-2 promoter activity by the FP_B prostanoid receptor

Hiromichi Fujino, John W. Regan

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We have recently shown that the FP_B prostanoid receptor activates β-catenin signaling through the activation of Rho in human embryo kidney (HEK)-293 cells stably expressing the FP_B receptors. We now report that the FP_B receptor can stimulate cyclooxygenase-2 promoter activity and may, therefore, regulate the expression of cyclooxygenase-2. This stimulation of cyclooxygenase-2 promoter activity is blocked by pretreatment with an inhibitor of Rho, but not with an inhibitor of protein kinase C (PKC). Potential up regulation of cyclooxygenase-2 expression by the FP_B receptor would establish a positive feedback loop that would drive β-catenin signaling and could be involved in cancer.

Original language	English (US)
Pages (from-to)	39-41
Number of pages	3
Journal	European Journal of Pharmacology
Volume	465
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-2999(03)01485-7
State	Published - Mar 28 2003

Keywords

Cyclooxygenase-2
FP prostanoid receptor
β-catenin signaling

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/S0014-2999(03)01485-7

Cite this

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title = "Prostaglandin F2α stimulation of cyclooxygenase-2 promoter activity by the FPB prostanoid receptor",

abstract = "We have recently shown that the FPB prostanoid receptor activates β-catenin signaling through the activation of Rho in human embryo kidney (HEK)-293 cells stably expressing the FPB receptors. We now report that the FPB receptor can stimulate cyclooxygenase-2 promoter activity and may, therefore, regulate the expression of cyclooxygenase-2. This stimulation of cyclooxygenase-2 promoter activity is blocked by pretreatment with an inhibitor of Rho, but not with an inhibitor of protein kinase C (PKC). Potential up regulation of cyclooxygenase-2 expression by the FPB receptor would establish a positive feedback loop that would drive β-catenin signaling and could be involved in cancer.",

keywords = "Cyclooxygenase-2, FP prostanoid receptor, β-catenin signaling",

author = "Hiromichi Fujino and Regan, {John W.}",

note = "Funding Information: We thank Dr. Inoue for providing the cyclooxygenase-2 reporter plasmid. This work is supported in part by the National Institutes of Health (EY11291), Allergan and the Arizona Disease Control Research Commission.",

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T1 - Prostaglandin F2α stimulation of cyclooxygenase-2 promoter activity by the FPB prostanoid receptor

AU - Fujino, Hiromichi

AU - Regan, John W.

N1 - Funding Information: We thank Dr. Inoue for providing the cyclooxygenase-2 reporter plasmid. This work is supported in part by the National Institutes of Health (EY11291), Allergan and the Arizona Disease Control Research Commission.

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Y1 - 2003/3/28

N2 - We have recently shown that the FPB prostanoid receptor activates β-catenin signaling through the activation of Rho in human embryo kidney (HEK)-293 cells stably expressing the FPB receptors. We now report that the FPB receptor can stimulate cyclooxygenase-2 promoter activity and may, therefore, regulate the expression of cyclooxygenase-2. This stimulation of cyclooxygenase-2 promoter activity is blocked by pretreatment with an inhibitor of Rho, but not with an inhibitor of protein kinase C (PKC). Potential up regulation of cyclooxygenase-2 expression by the FPB receptor would establish a positive feedback loop that would drive β-catenin signaling and could be involved in cancer.

AB - We have recently shown that the FPB prostanoid receptor activates β-catenin signaling through the activation of Rho in human embryo kidney (HEK)-293 cells stably expressing the FPB receptors. We now report that the FPB receptor can stimulate cyclooxygenase-2 promoter activity and may, therefore, regulate the expression of cyclooxygenase-2. This stimulation of cyclooxygenase-2 promoter activity is blocked by pretreatment with an inhibitor of Rho, but not with an inhibitor of protein kinase C (PKC). Potential up regulation of cyclooxygenase-2 expression by the FPB receptor would establish a positive feedback loop that would drive β-catenin signaling and could be involved in cancer.

KW - Cyclooxygenase-2

KW - FP prostanoid receptor

KW - β-catenin signaling

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