Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells

Hiromichi Fujino, Naofumi Seira, Naoki Kurata, Yumi Araki, Hiroyuki Nakamura, John W. Regan, Toshihiko Murayama

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Medicine & Life Sciences