Prospects for peptidomimetic drug design

Peptidomimetic drug design offers many exciting opportunities and challenges for the basic research scientist interested in understanding the chemical and physical principles critical for drug action, and for medicinal chemists, biochemists, molecular biologists and others to apply these principles to the next-generation of drugs. Considerable success already has been achieved, and it is likely that continued research in peptide and protein structural chemistry, coupled with the development of novel scaffolds and templates that can predictably mimic the stereoelectronic, stereostructural and dynamic properties of peptides and proteins, will provide the tools for successful de novo peptidomimetic design.