Prospects for building the tree of life from large sequence databases

Amy C. Driskell, Cécile Ané, J. Gordon Burleig, Michelle M. McMahon, Brian C. O'Meara, Michael J. Sanderson

Research output: Contribution to journalArticlepeer-review

208 Scopus citations


We assess the phylogenetic potential of ∼300,000 protein sequences sampled from Swiss-Prot and GenBank. Although only a small subset of these data was potentially phylogenetically informative, this subset retained a substantial fraction of the original taxonomic diversity. Sampling biases in the databases necessitate building phylogenetic data sets that have large numbers of missing entries. However, an analysis of two "supermatrices" suggests that even data sets with as much as 92% missing data can provide insights into broad sections of the tree of life.

Original languageEnglish (US)
Pages (from-to)1172-1174
Number of pages3
Issue number5699
StatePublished - Nov 12 2004

ASJC Scopus subject areas

  • General


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