Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines

Hexin Xie, Liansuo Zu, Hanine R. Oueis, Hao Li, Jian Wang, Wei Wang

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.

Original languageEnglish (US)
Pages (from-to)1923-1926
Number of pages4
JournalOrganic Letters
Volume10
Issue number10
DOIs
StatePublished - May 15 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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