Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines

Hexin Xie; Liansuo Zu; Hanine R. Oueis; Hao Li; Jian Wang; Wei Wang

doi:10.1021/ol800417q

Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines

Hexin Xie, Liansuo Zu, Hanine R. Oueis, Hao Li, Jian Wang, Wei Wang

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.

Original language	English (US)
Pages (from-to)	1923-1926
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	10
DOIs	https://doi.org/10.1021/ol800417q
State	Published - May 15 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol800417q

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title = "Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines",

abstract = "An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.",

author = "Hexin Xie and Liansuo Zu and Oueis, {Hanine R.} and Hao Li and Jian Wang and Wei Wang",

year = "2008",

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T1 - Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines

AU - Xie, Hexin

AU - Zu, Liansuo

AU - Oueis, Hanine R.

AU - Li, Hao

AU - Wang, Jian

AU - Wang, Wei

PY - 2008/5/15

Y1 - 2008/5/15

N2 - An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.

AB - An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.

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JO - Organic Letters

JF - Organic Letters

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Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines

Abstract

ASJC Scopus subject areas

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