Prolactin is a tumor promoter in rat liver

Arthur R. Buckley, Charles W. Putnam, Diane H. Russell

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Since prolactin, like the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, induces ornithine decarboxylase and plasminogen activator activities, biochemical markers of a trophic response, this hormone might likewise promote neoplasia. To test this theory, rats were initiated with a hepatocarcinogen followed by six weeks of ovine prolactin. This regimen caused hepatomegaly and the development of enzyme-altered foci. Promotion with prolactin for 23 weeks further increased the numbers of enzyme-altered foci. We suggest that prolactin is an endogenous tumor promoter for chemically initiated cells.

Original languageEnglish (US)
Pages (from-to)2569-2575
Number of pages7
JournalLife Sciences
Issue number26
StatePublished - Dec 30 1985

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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