Progress in liver transplantation

Charles W. Putnam, Charles G. Halgrimson, Lawrence Koep, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Since the first clinical orthotopic liver transplant was performed 13 years ago, approximately 275 patients have undergone this procedure. The Denver series constitutes about 40% of this total experience. In our series, the overall 1-year survival has been 29%; the longest survivor is now 6 2/3 years posttransplantation. Most of the early deaths have been caused by technical complications, frequently related to difficulties in establishing and maintaining adequate biliary drainage. The late deaths have been from a variety of causes, including recurrent tumor, hepatitis, bile duct obstruction, and chronic rejection. Favorable indications for liver transplantation include biliary atresia, chronic aggressive hepatitis, inborn errors of metabolism, and certain other benign hepatic diseases. Alcoholic cirrhosis is a less favorable indication and primary hepatic malignancy is a relative contraindication. The immunologic criteria for donor-recipient selection are much less rigid than for renal transplantation. Biliary reconstruction is the principal technical problem encountered with orthotopic liver transplantation. Guidelines for the establishment of biliary drainage, its evaluation, and the management of postoperative biliary complications are discussed.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalWorld journal of surgery
Issue number2
StatePublished - Mar 1977
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Progress in liver transplantation'. Together they form a unique fingerprint.

Cite this