Programmable Emulsions via Nucleophile-Induced Covalent Surfactant Modifications

Ann Fernandez; Cassandra A. Zentner; Manisha Shivrayan; Emil Samson; Suchol Savagatrup; Jiaming Zhuang; Timothy M. Swager; S. Thayumanavan

doi:10.1021/acs.chemmater.0c01107

Programmable Emulsions via Nucleophile-Induced Covalent Surfactant Modifications

Ann Fernandez, Cassandra A. Zentner, Manisha Shivrayan, Emil Samson, Suchol Savagatrup, Jiaming Zhuang, Timothy M. Swager, S. Thayumanavan

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Responsive surfactants designed with kinetic control are rare and offer new opportunities in generating tunable reactive assemblies. In this work, we discuss the design of novel molecular assemblies based on covalently triggerable surfactants programmed to respond exclusively to nucleophilic triggers to cause interfacial alterations. Through a formal SN2′-type Michael addition chemistry, these induced alterations at the interface of single and dynamic double emulsions can be kinetically tuned and brought about by various small molecule nucleophiles and functionalized nanoassemblies to cause macroscopic responses, such as bursting or morphology changes. In addition, separate responsive modalities can be used to further control the emulsion systems to enable cascade trigger behavior and programmed release applications.

Original language	English (US)
Pages (from-to)	4663-4671
Number of pages	9
Journal	Chemistry of Materials
Volume	32
Issue number	11
DOIs	https://doi.org/10.1021/acs.chemmater.0c01107
State	Published - Jun 9 2020
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Materials Chemistry

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10.1021/acs.chemmater.0c01107

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abstract = "Responsive surfactants designed with kinetic control are rare and offer new opportunities in generating tunable reactive assemblies. In this work, we discuss the design of novel molecular assemblies based on covalently triggerable surfactants programmed to respond exclusively to nucleophilic triggers to cause interfacial alterations. Through a formal SN2′-type Michael addition chemistry, these induced alterations at the interface of single and dynamic double emulsions can be kinetically tuned and brought about by various small molecule nucleophiles and functionalized nanoassemblies to cause macroscopic responses, such as bursting or morphology changes. In addition, separate responsive modalities can be used to further control the emulsion systems to enable cascade trigger behavior and programmed release applications.",

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AU - Fernandez, Ann

AU - Zentner, Cassandra A.

AU - Shivrayan, Manisha

AU - Samson, Emil

AU - Savagatrup, Suchol

AU - Zhuang, Jiaming

AU - Swager, Timothy M.

AU - Thayumanavan, S.

PY - 2020/6/9

Y1 - 2020/6/9

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AB - Responsive surfactants designed with kinetic control are rare and offer new opportunities in generating tunable reactive assemblies. In this work, we discuss the design of novel molecular assemblies based on covalently triggerable surfactants programmed to respond exclusively to nucleophilic triggers to cause interfacial alterations. Through a formal SN2′-type Michael addition chemistry, these induced alterations at the interface of single and dynamic double emulsions can be kinetically tuned and brought about by various small molecule nucleophiles and functionalized nanoassemblies to cause macroscopic responses, such as bursting or morphology changes. In addition, separate responsive modalities can be used to further control the emulsion systems to enable cascade trigger behavior and programmed release applications.

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Programmable Emulsions via Nucleophile-Induced Covalent Surfactant Modifications

Abstract

ASJC Scopus subject areas

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