@article{21b4849311d04265afbeff9cfb8ff791,
title = "Prognostic value of polygenic risk scores for adults with psychosis",
abstract = "Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor outcomes in real-world clinical practice. To date, few studies have assessed the prognostic value of PRS relative to standards of care. Schizophrenia (SCZ), the archetypal psychotic illness, is an ideal test case for this because the predictive power of the SCZ PRS exceeds that of most other common diseases. Here, we analyzed clinical and genetic data from two multi-ethnic cohorts totaling 8,541 adults with SCZ and related psychotic disorders, to assess whether the SCZ PRS improves the prediction of poor outcomes relative to clinical features captured in a standard psychiatric interview. For all outcomes investigated, the SCZ PRS did not improve the performance of predictive models, an observation that was generally robust to divergent case ascertainment strategies and the ancestral background of the study participants.",
author = "Isotta Landi and Kaji, {Deepak A.} and Liam Cotter and {Van Vleck}, Tielman and Gillian Belbin and Michael Preuss and Loos, {Ruth J.F.} and Eimear Kenny and Glicksberg, {Benjamin S.} and Beckmann, {Noam D.} and Paul O{\textquoteright}Reilly and Schadt, {Eric E.} and Achtyes, {Eric D.} and Buckley, {Peter F.} and Douglas Lehrer and Malaspina, {Dolores P.} and McCarroll, {Steven A.} and Rapaport, {Mark H.} and Fanous, {Ayman H.} and Pato, {Michele T.} and Pato, {Carlos N.} and Bigdeli, {Tim B.} and Nadkarni, {Girish N.} and Charney, {Alexander W.}",
note = "Funding Information: This study was supported by grant R01 MH121923 from the National Institute of Mental Health (NIMH). The authors thank A. Jain, A. Moscati, L. Zhou, Q. Song, S. Wenric and S. Ellis, all of whom are paid employees of the Icahn School of Medicine at Mount Sinai, for assisting with quality control and/or file handling for the BioMe exome sequencing and genome-wide genotyping data. The BioMe healthcare delivery cohort at Mount Sinai was established and maintained with a generous gift from the Andrea and Charles Bronfman Philanthropies. The authors also thank the Genomic Psychiatry Cohort (GPC) Investigators. The GPC was supported by grants R01 MH085548, R01 MH104964 and R01 MH123451-01 from the NIMH, and genotyping of samples was provided by the Stanley Center for Psychiatric Research at Broad Institute. T.B.B. is supported by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2021",
month = sep,
doi = "10.1038/s41591-021-01475-7",
language = "English (US)",
volume = "27",
pages = "1576--1581",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "9",
}