Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Jason R. Porter; Mark R. Helmers; Ping Wang; Jennifer L. Furman; Stephen T. Joy; Paramjit S. Arora; Indraneel Ghosh

doi:10.1039/c0cc02969f

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Jason R. Porter
, Mark R. Helmers
, Ping Wang
, Jennifer L. Furman
, Stephen T. Joy
, Paramjit S. Arora
, Indraneel Ghosh

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Original language	English (US)
Pages (from-to)	8020-8022
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	42
DOIs	https://doi.org/10.1039/c0cc02969f
State	Published - Nov 14 2010

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c0cc02969f

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title = "Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2",

abstract = "We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.",

author = "Porter, \{Jason R.\} and Helmers, \{Mark R.\} and Ping Wang and Furman, \{Jennifer L.\} and Joy, \{Stephen T.\} and Arora, \{Paramjit S.\} and Indraneel Ghosh",

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T2 - The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

AU - Porter, Jason R.

AU - Helmers, Mark R.

AU - Wang, Ping

AU - Furman, Jennifer L.

AU - Joy, Stephen T.

AU - Arora, Paramjit S.

AU - Ghosh, Indraneel

PY - 2010/11/14

Y1 - 2010/11/14

N2 - We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

AB - We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

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UR - https://www.scopus.com/pages/publications/77958455528#tab=citedBy

U2 - 10.1039/c0cc02969f

DO - 10.1039/c0cc02969f

M3 - Article

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AN - SCOPUS:77958455528

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EP - 8022

JO - Chemical Communications

JF - Chemical Communications

IS - 42

ER -

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Abstract

ASJC Scopus subject areas

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