Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Jason R. Porter; Mark R. Helmers; Ping Wang; Jennifer L. Furman; Stephen T. Joy; Paramjit S. Arora; Indraneel Ghosh

doi:10.1039/c0cc02969f

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Jason R. Porter, Mark R. Helmers, Ping Wang, Jennifer L. Furman, Stephen T. Joy, Paramjit S. Arora, Indraneel Ghosh

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Original language	English (US)
Pages (from-to)	8020-8022
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	42
DOIs	https://doi.org/10.1039/c0cc02969f
State	Published - Nov 14 2010

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c0cc02969f

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title = "Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2",

abstract = "We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.",

author = "Porter, {Jason R.} and Helmers, {Mark R.} and Ping Wang and Furman, {Jennifer L.} and Joy, {Stephen T.} and Arora, {Paramjit S.} and Indraneel Ghosh",

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AU - Porter, Jason R.

AU - Helmers, Mark R.

AU - Wang, Ping

AU - Furman, Jennifer L.

AU - Joy, Stephen T.

AU - Arora, Paramjit S.

AU - Ghosh, Indraneel

PY - 2010/11/14

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JO - Chemical Communications

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Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Abstract

ASJC Scopus subject areas

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