Profiles of Caregiver-Reported Executive Function in Children with Down Syndrome

Kaylyn Van Deusen, Mark A. Prince, Anna J. Esbensen, Jamie O. Edgin, Emily K. Schworer, Angela John Thurman, Lina R. Patel, Lisa A. Daunhauer, Deborah J. Fidler

Research output: Contribution to journalArticlepeer-review


Children with Down syndrome (DS) are at risk for challenges with aspects of executive function (EF). The current study explores whether heterogeneity in EF profiles can be detected within a sample of children with DS. Participants were 69 children with DS, ages 3–10 years (M = 6.23, SD = 1.91). T-scores from a caregiver-report measure of executive function were modeled using latent profile analysis, and auxiliary analyses examined the association between demographic and biomedical factors and probability of profile membership. The two-profile solution was the best fit for the sample, with a profile that involved elevated scores in working memory only (“Working Memory Only” profile; 43% of sample) and a “Multi-Domain” profile that involved elevated scores in planning, inhibition, and working memory (57%). The presence of congenital heart defects was associated with a higher probability of assignment to the Multi-Domain profile. Findings from this study contribute to the characterization of heterogeneous outcomes associated with DS.

Original languageEnglish (US)
Article number1333
JournalBrain Sciences
Issue number10
StatePublished - Oct 2022


  • Down syndrome
  • executive function
  • latent profile analysis

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Profiles of Caregiver-Reported Executive Function in Children with Down Syndrome'. Together they form a unique fingerprint.

Cite this