Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry

Sophie R. Harvey; Zachary L. Vanaernum; Marius M. Kostelic; Michael T. Marty; Vicki H. Wysocki

doi:10.1039/d0cc05531j

Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry

Sophie R. Harvey, Zachary L. Vanaernum, Marius M. Kostelic, Michael T. Marty, Vicki H. Wysocki

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In the study of membrane proteins and antimicrobial peptides, nanodiscs have emerged as a valuable membrane mimetic to solubilze these molecules in a lipid bilayer. We present the structural characterization of nanodiscs using native mass spectrometry and surface-induced dissociation, which are powerful tools in structural biology.

Original language	English (US)
Pages (from-to)	15651-15654
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	100
DOIs	https://doi.org/10.1039/d0cc05531j
State	Published - Dec 28 2020

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

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10.1039/d0cc05531j

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abstract = "In the study of membrane proteins and antimicrobial peptides, nanodiscs have emerged as a valuable membrane mimetic to solubilze these molecules in a lipid bilayer. We present the structural characterization of nanodiscs using native mass spectrometry and surface-induced dissociation, which are powerful tools in structural biology.",

author = "Harvey, {Sophie R.} and Vanaernum, {Zachary L.} and Kostelic, {Marius M.} and Marty, {Michael T.} and Wysocki, {Vicki H.}",

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AU - Vanaernum, Zachary L.

AU - Kostelic, Marius M.

AU - Marty, Michael T.

AU - Wysocki, Vicki H.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2020/12/28

Y1 - 2020/12/28

N2 - In the study of membrane proteins and antimicrobial peptides, nanodiscs have emerged as a valuable membrane mimetic to solubilze these molecules in a lipid bilayer. We present the structural characterization of nanodiscs using native mass spectrometry and surface-induced dissociation, which are powerful tools in structural biology.

AB - In the study of membrane proteins and antimicrobial peptides, nanodiscs have emerged as a valuable membrane mimetic to solubilze these molecules in a lipid bilayer. We present the structural characterization of nanodiscs using native mass spectrometry and surface-induced dissociation, which are powerful tools in structural biology.

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Probing the structure of nanodiscs using surface-induced dissociation mass spectrometry

Abstract

ASJC Scopus subject areas

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