Probes for Narcotic Receptor Mediated Phenomena. 19.1 Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist

Silvia N. Calderon; Richard B. Rothman; Frank Porreca; Judith L. Flippen-Anderson; Robert W. McNutt; Heng Xu; Larren E. Smith; Edward J. Bilsky; Peg Davis; Kenner C. Rice

doi:10.1021/jm00040a002

Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist

Silvia N. Calderon, Richard B. Rothman, Frank Porreca, Judith L. Flippen-Anderson, Robert W. McNutt, Heng Xu, Larren E. Smith, Edward J. Bilsky, Peg Davis, Kenner C. Rice

Research output: Contribution to journal › Article › peer-review

229 Scopus citations

Original language	English (US)
Pages (from-to)	2125-2128
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	37
Issue number	14
DOIs	https://doi.org/10.1021/jm00040a002
State	Published - Jul 1 1994

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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Calderon, S. N., Rothman, R. B., Porreca, F., Flippen-Anderson, J. L., McNutt, R. W., Xu, H., Smith, L. E., Bilsky, E. J., Davis, P., & Rice, K. C. (1994). Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist. Journal of Medicinal Chemistry, 37(14), 2125-2128. https://doi.org/10.1021/jm00040a002

Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist. / Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank et al.
In: Journal of Medicinal Chemistry, Vol. 37, No. 14, 01.07.1994, p. 2125-2128.

Research output: Contribution to journal › Article › peer-review

Calderon, SN, Rothman, RB, Porreca, F, Flippen-Anderson, JL, McNutt, RW, Xu, H, Smith, LE, Bilsky, EJ, Davis, P & Rice, KC 1994, 'Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist', Journal of Medicinal Chemistry, vol. 37, no. 14, pp. 2125-2128. https://doi.org/10.1021/jm00040a002

Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H et al. Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist. Journal of Medicinal Chemistry. 1994 Jul 1;37(14):2125-2128. doi: 10.1021/jm00040a002

Calderon, Silvia N. ; Rothman, Richard B. ; Porreca, Frank et al. / Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80) : A Highly Selective, Nonpeptide δ Opioid Receptor Agonist. In: Journal of Medicinal Chemistry. 1994 ; Vol. 37, No. 14. pp. 2125-2128.

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Probes for Narcotic Receptor Mediated Phenomena. 19.1 Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist

ASJC Scopus subject areas

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Probes for Narcotic Receptor Mediated Phenomena. 19.₁ Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist