Probes containing gamma radiation detectors for in vivo tumor detection and imaging

N. E. Hartsough, H. B. Barber, J. M. Woolfenden, H. H. Barrett, T. S. Hickernell, D. P. Kwo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


External gamma-camera imaging using tumor-seeking radiotracers has been shown to be insensitive in the task of identifying small tumors situated deep inside the body. Our approach is to use probes containing miniature radiation detectors which, when maneuvered close to a tumor, overcome the limitations of external imaging. We discuss our results from using such probes for bronchoscopic and surgical tumor detection. A limitation that prevents the detection of small tumors with these probes is the spatial variation of the background count rate due to distant background sources of high radiotracer uptake. We present two techniques for solving this problem; geometric background subtraction and imaging.

Original languageEnglish (US)
Pages (from-to)92-99
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Aug 8 1989

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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